Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782272 | 0.96 | DRD2 (0.56) | DRD2DRD3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL2784944 | 0.93 | ALDH1A1 (0.50) | DRD2DRD3KDM4EALDH1A1POLB | |
| SCHEMBL2782952 | 0.81 | DRD2 (0.59) | DRD2DRD3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL2781296 | 0.81 | ALDH1A1 (0.49) | DRD2KDM4EALDH1A1POLBTSHR | |
| SCHEMBL4960473 | 0.80 | CYP1A2 (0.50) | KDM4EALDH1A1POLBTSHRTDP1 | |
| SCHEMBL5505609 | 0.80 | DRD2 (0.52) | DRD2DRD3SIGMAR1TSHR | |
| SCHEMBL2785237 | 0.80 | DRD2 (0.57) | DRD2DRD3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL5502304 | 0.80 | DRD2 (0.38) | DRD2DRD3KDM4EALDH1A1TSHR | |
| SCHEMBL2781553 | 0.78 | DRD2 (0.73) | DRD2DRD3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL2783817 | 0.78 | DRD2 (0.73) | DRD2DRD3SIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |