Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5512094 | 0.93 | ACHE (0.56) | ACHEBCHEALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5508236 | 0.89 | ACHE (0.40) | ACHEBCHEALDH1A1L3MBTL1KMT2A | |
| SCHEMBL5511672 | 0.87 | ACHE (0.38) | ACHEBCHEALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5508196 | 0.87 | GAA (0.41) | ACHEBCHEL3MBTL1GAA | |
| SCHEMBL5511760 | 0.85 | ELANE (0.39) | ACHEBCHEL3MBTL1MAPTGAA | |
| SCHEMBL5508714 | 0.82 | ACHE (0.44) | ACHEBCHEALDH1A1L3MBTL1KMT2A | |
| SCHEMBL5509751 | 0.82 | ACHE (0.44) | ACHEBCHEALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5506377 | 0.81 | ACHE (0.42) | ACHEBCHEALDH1A1L3MBTL1KMT2A | |
| SCHEMBL5511094 | 0.81 | GAA (0.43) | ACHEBCHEL3MBTL1GAA | |
| SCHEMBL5510773 | 0.81 | TUBB4A (0.43) | ACHEBCHEALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521583-B1 | 7,8,9,10-TETRAHYDRO-6H-AZEPINO, 6,7,8,9-TETRAHYDRO-PYRIDO AND 2,3-DIHYDRO-2H-PYRROLO (2,1-B)-QUINAZOLINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-01-10 | — | — | EP | disclosed |
| US-7067519-B2 | 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2006-06-27 | — | — | US | disclosed |
| EP-1521583-A1 | 7,8,9,10-TETRAHYDRO-6H-AZEPINO, 6,7,8,9-TETRAHYDRO-PYRIDO AND 2,3-DIHYDRO-2H-PYRROLO (2,1-B)-QUINAZOLINONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-13 | — | — | EP | disclosed |
| US-20050009852-A1 | 7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates | ACTELION PHARMACEUTICALS, LTD. (CH) | 2005-01-13 | — | — | US | disclosed |
| WO-2004004733-A1 | 7,8,9,10-TETRAHYDRO-6H-AZEPINO, 6,7,8,9-TETRAHYDRO-PYRIDO AND 2,3-DIHYDRO-2H-PYRROLO[2,1-B]-QUINAZOLINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009852-A1 | 7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates | HCRTR2, HCRTR1, NPY1R | ACHE 2967/4885BCHE 2964/4885ALDH1A1 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.