Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.44 |
| ▸ | DRD3 | P35462 | 12/20 | 0.44 |
| ▸ | DRD4 | P21917 | 10/20 | 0.44 |
| ▸ | DRD1 | P21728 | 8/20 | 0.44 |
| ▸ | DRD5 | P21918 | 8/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503057 | 0.80 | DRD2 (0.43) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2784338 | 0.80 | DRD2 (0.50) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2783391 | 0.79 | DRD2 (0.54) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL5533630 | 0.78 | DRD2 (0.39) | DRD2DRD3DRD1DRD5 | |
| SCHEMBL2783753 | 0.76 | DRD2 (0.62) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2782002 | 0.72 | RBP4 (0.46) | DRD2 | |
| SCHEMBL2781883 | 0.71 | DRD3 (0.53) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2782288 | 0.70 | DRD2 (0.51) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2783726 | 0.70 | DRD2 (0.51) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2781896 | 0.70 | DRD2 (0.54) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |