Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2154937 | 0.94 | MMP13 (0.44) | ALDH1A1PKMCYP3A4MMP13MMP14 | |
| SCHEMBL5506445 | 0.93 | LMNA (0.35) | LMNAALDH1A1PKMHTTCYP3A4 | |
| SCHEMBL2154754 | 0.92 | CYP3A4 (0.43) | LMNACYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL2155138 | 0.84 | MMP13 (0.50) | CYP3A4MMP13MMP14ADAMTS4KCNH2 | |
| SCHEMBL2154919 | 0.82 | MMP13 (0.49) | LMNACYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL2155266 | 0.82 | CYP3A4 (0.42) | LMNAALDH1A1CYP3A4MMP13MMP14 | |
| SCHEMBL2155110 | 0.79 | MMP13 (0.63) | ALDH1A1CYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL27693742 | 0.79 | MMP13 (0.50) | ALDH1A1CYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL2155381 | 0.79 | MMP13 (0.44) | LMNAALDH1A1PKMHTTCYP3A4 | |
| SCHEMBL2155625 | 0.78 | MAPT (0.37) | ALDH1A1PKMMAPTTHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | claimed |