Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | SLC8A1 | P32418 | 4/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506543 | 1.00 | RAB9A (0.35) | RAB9AATP4AATP4BDHODHSLC8A1 | |
| SCHEMBL4663178 | 0.92 | DHODH (0.36) | RAB9AATP4AATP4BDHODHSLC8A1 | |
| SCHEMBL6019450 | 0.92 | DHODH (0.36) | RAB9AATP4AATP4BDHODHSLC8A1 | |
| SCHEMBL6020045 | 0.92 | DHODH (0.36) | RAB9AATP4AATP4BDHODHSLC8A1 | |
| SCHEMBL4666543 | 0.90 | RAB9A (0.35) | RAB9AATP4AATP4BDHODHSLC8A1 | |
| SCHEMBL4662902 | 0.88 | RIPK1 (0.36) | RAB9AATP4AATP4BDHODHSLC8A1 | |
| SCHEMBL4664616 | 0.88 | RIPK1 (0.36) | RAB9AATP4AATP4BDHODHSLC8A1 | |
| SCHEMBL4664869 | 0.88 | MEN1 (0.39) | RAB9ASLC8A1 | |
| SCHEMBL5116463 | 0.88 | RAB9A (0.36) | RAB9AATP4AATP4BSLC8A1 | |
| SCHEMBL4664655 | 0.88 | RAB9A (0.36) | RAB9AATP4AATP4BSLC8A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863820-A1 | THIOAMIDE-SUBSTITUTED TRICYCLIC BENZIMIDAZOLES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISEASES | Nycomed GmbH (DE) | 2007-12-12 | — | — | EP | claimed |
| WO-2006100255-A1 | THIOAMIDE-SUBSTITUTED TRICYCLIC BENZIMIDAZOLES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISEASES | NYCOMED GMBH (DE) | 2006-09-28 | — | — | WO | claimed |