Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 11/20 | 0.48 |
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.46 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506559 | 0.99 | POLB (0.48) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5506565 | 0.92 | TDP1 (0.47) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5507292 | 0.91 | TDP1 (0.49) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5507280 | 0.89 | TDP1 (0.49) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5505065 | 0.89 | POLB (0.47) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5505632 | 0.89 | CA5A (0.43) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5505628 | 0.88 | ALDH1A1 (0.43) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5505618 | 0.87 | CA5A (0.43) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5505617 | 0.87 | ALDH1A1 (0.43) | POLBMAPTTDP1SLC22A6SLC22A8 | |
| SCHEMBL5505123 | 0.87 | CA5A (0.40) | POLBMAPTTDP1SLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841339-B1 | Vinylpyrrolidinon cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |