Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4004183 | 0.92 | TSHR (0.60) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL3998128 | 0.90 | KDM4E (0.71) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL4001104 | 0.89 | KDM4E (0.69) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL1546461 | 0.83 | TSHR (0.59) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL11184423 | 0.83 | KMT2A (0.68) | KDM4EKMT2AALDH1A1MEN1TSHR | |
| SCHEMBL11178802 | 0.81 | KMT2A (0.65) | KDM4EKMT2AALDH1A1MEN1TSHR | |
| SCHEMBL11180002 | 0.81 | TSHR (0.73) | KDM4EKMT2AALDH1A1MEN1TSHR | |
| SCHEMBL4006356 | 0.80 | ALDH1A1 (0.61) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL3997775 | 0.79 | ALDH1A1 (0.64) | KDM4ETDP1KMT2AALDH1A1TSHR | |
| SCHEMBL3999221 | 0.79 | ALDH1A1 (0.62) | KDM4ETDP1KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861376-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F. Hoffmann-Roche AG (CH) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097261-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-21 | — | — | WO | disclosed |