Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 6/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5432642 | 0.86 | PLAU (0.41) | PLAUACACBQPCTACACACNR1 | |
| SCHEMBL3581119 | 0.80 | PLAU (0.43) | PLAUSRC | |
| SCHEMBL3581122 | 0.80 | PLAU (0.43) | PLAUSRC | |
| SCHEMBL5427453 | 0.78 | ACACB (0.40) | ACACBQPCTACACACNR1CNR2 | |
| SCHEMBL5530317 | 0.74 | KCNH2 (0.47) | ACACBACACACNR1CNR2CKS1B | |
| SCHEMBL5506645 | 0.73 | KDM4E (0.41) | ACACBACACACNR1CNR2DRD2 | |
| SCHEMBL5264985 | 0.73 | MTNR1B (0.47) | ACACBQPCTACACAIRAK1 | |
| SCHEMBL3576655 | 0.71 | MEN1 (0.34) | PLAUSRCPIM1PIM2 | |
| SCHEMBL5511359 | 0.70 | CYP2C9 (0.43) | IRAK1 | |
| SCHEMBL5439560 | 0.70 | KCNH2 (0.48) | ACACBACACACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |