Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.61 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967241 | 0.87 | PRMT5 (0.47) | PRMT5WDR77SLC6A4CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL709865 | 0.86 | PRMT5 (0.46) | PRMT5WDR77SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL15967360 | 0.81 | CHRM2 (0.50) | SLC6A4CYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL5510485 | 0.80 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL3783316 | 0.79 | PRMT5 (0.51) | PRMT5WDR77SLC6A4CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL708458 | 0.79 | CHRM2 (0.49) | SLC6A4CYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL18726738 | 0.79 | SLC6A4 (0.50) | PRMT5WDR77SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL3783254 | 0.77 | PRMT5 (0.49) | PRMT5WDR77CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5509008 | 0.75 | TSHR (0.47) | TSHRHPGDALDH1A1LMNA | |
| SCHEMBL3777733 | 0.74 | PRMT5 (0.41) | PRMT5WDR77SLC6A4CYP2C9SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |