Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MARS1 | P56192 | 5/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | DBH | P09172 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967360 | 0.84 | CHRM2 (0.50) | HTR2CCXCR4CHRM2 | |
| Hydrochloric Acid SCHEMBL708458 | 0.83 | CHRM2 (0.49) | CXCR4CHRM2 | |
| SCHEMBL5506772 | 0.80 | PRMT5 (0.61) | PRMT5WDR77 | |
| SCHEMBL15967241 | 0.79 | PRMT5 (0.47) | PRMT5WDR77KMT2A | |
| Hydrochloric Acid SCHEMBL709865 | 0.78 | PRMT5 (0.46) | PRMT5WDR77KMT2A | |
| SCHEMBL3778327 | 0.78 | CACNA1H (0.40) | PRMT5WDR77KDM1ACACNA1HDBH | |
| SCHEMBL5509008 | 0.75 | TSHR (0.47) | KDM1ADBHKMT2AP2RX7 | |
| SCHEMBL15967384 | 0.75 | CACNA1H (0.41) | KDM1ACACNA1HKMT2AP2RX7CXCR4 | |
| Hydrochloric Acid SCHEMBL711026 | 0.74 | CACNA1H (0.40) | KDM1ACACNA1HCXCR4 | |
| SCHEMBL15967032 | 0.73 | TAAR1 (0.49) | KMT2AHTR2CCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |