Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009532 | 0.87 | KMT2A (0.58) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL20830918 | 0.85 | KMT2A (0.67) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL7370844 | 0.84 | SMN1; SMN2 (0.55) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL4500586 | 0.82 | KMT2A (0.67) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL340618 | 0.82 | MAOB (0.67) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL11408485 | 0.82 | KMT2A (0.76) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL6539797 | 0.82 | ALDH1A1 (0.62) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL50807 | 0.80 | KMT2A (0.73) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL21546008 | 0.80 | KMT2A (0.59) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL2830303 | 0.80 | KMT2A (0.59) | KMT2ASLC6A2SLC6A3TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848688-A2 | INHIBITORS OF TRANSTHYRETIN AMYLOID FIBRIL FORMATION | The Scripps Research Institute (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006086517-A2 | INHIBITORS OF TRANSTHYRETIN AMYLOID FIBRIL FORMATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-08-17 | — | — | WO | disclosed |