Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 6/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511779 | 0.77 | MTNR1B (0.47) | MTNR1BMTNR1APIK3CAPIK3CDPIK3CB | |
| SCHEMBL5511774 | 0.77 | MTNR1B (0.47) | MTNR1BMTNR1APIK3CAPIK3CDPIK3CB | |
| SCHEMBL5511776 | 0.77 | MTNR1B (0.47) | MTNR1BMTNR1APIK3CAPIK3CDPIK3CB | |
| SCHEMBL632999 | 0.76 | PIK3CD (0.51) | MTNR1BMTNR1APIK3CAPIK3CDPIK3CB | |
| SCHEMBL3117210 | 0.73 | MTNR1B (0.46) | MTNR1BMTNR1AENPP1KDM4EIRAK4 | |
| SCHEMBL5507684 | 0.70 | CA1 (0.40) | MTNR1BMTNR1APIK3CAPIK3CDPIK3CB | |
| SCHEMBL5503330 | 0.70 | MTNR1B (0.43) | MTNR1BMTNR1AENPP1MAPK7KDM4E | |
| SCHEMBL3251044 | 0.69 | MTNR1B (0.53) | MTNR1BMTNR1AENPP1KDM4ELMNA | |
| SCHEMBL3251040 | 0.69 | MTNR1B (0.53) | MTNR1BMTNR1AENPP1KDM4ELMNA | |
| SCHEMBL632812 | 0.69 | PIK3CD (0.76) | MTNR1BPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |