Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 17/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.44 |
| ▸ | HTR2A | P28223 | 7/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506940 | 0.82 | SLC6A4 (0.45) | SLC6A4SLC6A2KCNH2SLC6A3HTR2A | |
| SCHEMBL5501246 | 0.81 | TAAR1 (0.50) | SLC6A4SLC6A2KCNH2SLC6A3HTR2A | |
| SCHEMBL5501242 | 0.81 | SLC6A4 (0.67) | SLC6A4SLC6A2KCNH2SLC6A3HTR2A | |
| SCHEMBL5498154 | 0.67 | SLC6A4 (0.50) | SLC6A4SLC6A2KCNH2SLC6A3HTR2A | |
| SCHEMBL5498157 | 0.67 | TAAR1 (0.52) | HTR2A | |
| SCHEMBL5501642 | 0.66 | TAAR1 (0.51) | HTR2AMAPT | |
| SCHEMBL146841 | 0.66 | CA1 (0.61) | KDM4EMAPT | |
| SCHEMBL11313806 | 0.65 | MAPT (0.59) | SLC6A4SLC6A2KCNH2SLC6A3HTR2A | |
| Hydrochloric Acid SCHEMBL5457539 | 0.65 | TAAR1 (0.50) | HTR2A | |
| SCHEMBL5501635 | 0.65 | SLC6A4 (0.58) | SLC6A4SLC6A2KCNH2SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791807-A1 | THERAPEUTIC DIPHENYL ETHER LIGANDS | Pfizer Products Incorporated (US) | 2007-06-06 | — | — | EP | claimed |
| WO-2006027684-A1 | THERAPEUTIC DIPHENYL ETHER LIGANDS | PFIZER PRODUCTS INC. (US) | 2006-03-16 | — | — | WO | claimed |