Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 0.55 |
| ▸ | DRD2 | P14416 | 11/20 | 0.55 |
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | FAAH | O00519 | 2/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510393 | 0.89 | DRD2 (0.57) | DRD3DRD2DRD4ADRA1AKCNH2 | |
| SCHEMBL5512380 | 0.87 | DRD2 (0.57) | DRD3DRD2DRD4ADRA1AHTR2A | |
| SCHEMBL5509766 | 0.87 | DRD2 (0.55) | DRD3DRD2DRD4ADRA1AHTR2A | |
| SCHEMBL5468576 | 0.85 | DRD3 (0.53) | DRD3DRD2DRD4ADRA1AKCNH2 | |
| SCHEMBL4947482 | 0.82 | HTR1A (0.42) | DRD3DRD2HTR2AHTR1A | |
| SCHEMBL4950295 | 0.82 | DRD2 (0.46) | DRD3DRD2HTR2AHTR1A | |
| SCHEMBL4950371 | 0.80 | HTR1A (0.47) | DRD3DRD2HTR2AHTR1A | |
| SCHEMBL4950173 | 0.79 | HTR1A (0.46) | DRD3DRD2HTR2AHTR1A | |
| SCHEMBL4950706 | 0.79 | HTR1A (0.41) | DRD3DRD2DRD4HTR2AHTR1A | |
| SCHEMBL4952283 | 0.78 | HTR1A (0.45) | DRD3DRD2DRD4HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519726-B1 | UTILIZATION OF HETEROARENE CARBOXAMIDE AS DOPAMINE-D3 LIGANDS FOR THE TREATMENT OF CNS DISEASES | SANOL ARZNEI SCHWARZ GMBH (DE) | 2007-02-21 | — | — | EP | claimed |