Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550724 | 1.00 | HTR7 (0.42) | HTR7HSD11B1CYP17A1HCRTR1HCRTR2 | |
| SCHEMBL2699553 | 1.00 | HTR7 (0.42) | HTR7HSD11B1CYP17A1HCRTR1HCRTR2 | |
| SCHEMBL2699556 | 1.00 | HTR7 (0.42) | HTR7HSD11B1CYP17A1HCRTR1HCRTR2 | |
| SCHEMBL553721 | 1.00 | HTR7 (0.42) | HTR7HSD11B1CYP17A1HCRTR1HCRTR2 | |
| SCHEMBL553722 | 1.00 | HTR7 (0.42) | HTR7HSD11B1CYP17A1HCRTR1HCRTR2 | |
| SCHEMBL5631870 | 0.90 | HTR7 (0.43) | HTR7HSD11B1CYP17A1PTPN11 | |
| SCHEMBL4724244 | 0.90 | HTR7 (0.43) | HTR7HSD11B1CYP17A1PTPN11 | |
| SCHEMBL550718 | 0.83 | HSD11B1 (0.41) | HSD11B1HCRTR1HCRTR2 | |
| SCHEMBL550719 | 0.83 | HSD11B1 (0.41) | HSD11B1HCRTR1HCRTR2 | |
| SCHEMBL550847 | 0.81 | HSD11B1 (0.41) | HSD11B1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |