Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507261 | 0.82 | LMNA (0.43) | LMNANPSR1CA12CA1CA2 | |
| SCHEMBL9044624 | 0.81 | DRD4 (0.52) | CHRNB2CHRNA4 | |
| SCHEMBL16493549 | 0.78 | MAPT (0.47) | LMNATP53POLBMAPTALDH1A1 | |
| SCHEMBL2157226 | 0.78 | CYP3A4 (0.44) | LMNANPSR1TP53ALDH1A1USP2 | |
| SCHEMBL2155444 | 0.77 | LMNA (0.51) | LMNANPSR1CA12CA1CA2 | |
| SCHEMBL2155435 | 0.77 | LMNA (0.51) | LMNANPSR1CA12CA1CA2 | |
| SCHEMBL2155931 | 0.77 | LMNA (0.51) | LMNANPSR1CA12CA1CA2 | |
| SCHEMBL16493579 | 0.77 | LMNA (0.52) | LMNATP53POLBALDH1A1 | |
| SCHEMBL4958223 | 0.76 | MMP13 (0.49) | LMNATP53POLBALDH1A1 | |
| SCHEMBL2156824 | 0.76 | TP53 (0.44) | LMNANPSR1TP53POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | disclosed |
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | disclosed |