Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138840 | 0.82 | PTGDR2 (0.63) | KMT2APTGDR2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5504734 | 0.79 | PTGDR2 (0.58) | KMT2APTGDR2LMNAMAPT | |
| SCHEMBL5513344 | 0.77 | PTGDR2 (0.56) | KMT2APTGDR2LMNAMAPT | |
| SCHEMBL13776309 | 0.73 | PTGDR2 (0.65) | KMT2APTGDR2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5497575 | 0.73 | PTGDR2 (0.74) | KMT2APTGDR2LMNASMN1; SMN2 | |
| SCHEMBL5444441 | 0.71 | PTGDR2 (0.52) | KMT2APTGDR2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6977049 | 0.68 | LMNA (0.76) | PTGDR2LMNASMN1; SMN2 | |
| SCHEMBL6972361 | 0.66 | LMNA (0.72) | PTGDR2LMNASMN1; SMN2 | |
| SCHEMBL6972357 | 0.66 | LMNA (0.72) | PTGDR2LMNASMN1; SMN2 | |
| SCHEMBL6972352 | 0.66 | LMNA (0.72) | PTGDR2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740547-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-10 | — | — | EP | claimed |
| WO-2005100321-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | WO | claimed |