Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.73 |
| ▸ | NPC1 | O15118 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GCGR | P47871 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5106058 | 0.83 | NPC1 (0.74) | RAB9ANPC1LMNASMN1; SMN2RECQL | |
| SCHEMBL5106063 | 0.77 | RAB9A (0.74) | RAB9ANPC1LMNASMN1; SMN2RECQL | |
| SCHEMBL5121659 | 0.75 | PTGDR2 (0.75) | MAPTPTGDR2DRD2TBXA2R | |
| SCHEMBL1063187 | 0.73 | CYP2E1 (0.68) | RAB9ANPC1LMNASMN1; SMN2RECQL | |
| SCHEMBL11119849 | 0.73 | KMT2A (0.60) | RAB9ANPC1KMT2APOLBTP53 | |
| SCHEMBL17161367 | 0.72 | HRH4 (0.47) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5113091 | 0.72 | PTGDR2 (0.51) | RAB9ANPC1LMNASMN1; SMN2RECQL | |
| SCHEMBL1061025 | 0.72 | RAB9A (0.77) | RAB9ANPC1LMNASMN1; SMN2RECQL | |
| SCHEMBL9288431 | 0.72 | SMN1; SMN2 (0.55) | RAB9ANPC1LMNASMN1; SMN2MEN1 | |
| SCHEMBL32688027 | 0.71 | MEN1 (0.66) | RAB9ANPC1LMNASMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |