Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | BRD3 | Q15059 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | BRD2 | P25440 | 2/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509086 | 0.89 | BRD4 (0.48) | BRD4TP53BRD3POLBBRD2 | |
| SCHEMBL3996870 | 0.89 | BRD4 (0.47) | BRD4TP53BRD3POLBSMN1; SMN2 | |
| SCHEMBL5511872 | 0.88 | BRD4 (0.52) | BRD4TP53CASP1BRD3POLB | |
| SCHEMBL5516306 | 0.87 | ALDH1A1 (0.44) | BRD4TP53POLBSMN1; SMN2HTT | |
| SCHEMBL5510395 | 0.85 | MEN1 (0.46) | SMN1; SMN2GAA | |
| SCHEMBL5622868 | 0.83 | BRD4 (0.52) | BRD4TP53CASP1BRD3POLB | |
| SCHEMBL5509333 | 0.83 | BRD4 (0.52) | BRD4TP53CASP1BRD3POLB | |
| SCHEMBL5505156 | 0.81 | BRD4 (0.46) | BRD4TP53CASP1BRD3POLB | |
| SCHEMBL5508350 | 0.80 | BRD4 (0.48) | BRD4TP53BRD3SMN1; SMN2BRD2 | |
| SCHEMBL5513699 | 0.80 | BRD4 (0.46) | BRD4TP53BRD3POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |