Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507345 | 0.85 | CCR2 (0.42) | GLSSLC6A9KCNH2MAPK1ROCK2 | |
| SCHEMBL15967172 | 0.84 | GLS (0.49) | GLSSLC6A9KCNH2CARM1PRMT6 | |
| SCHEMBL5509111 | 0.84 | KCNA5 (0.48) | GLSSLC6A9KCNH2CARM1PRMT6 | |
| SCHEMBL5533114 | 0.84 | GLS (0.46) | GLSSLC6A9KCNH2CARM1PRMT6 | |
| SCHEMBL15967037 | 0.83 | CARM1 (0.45) | GLSSLC6A9KCNH2CARM1PRMT6 | |
| SCHEMBL5513288 | 0.83 | CARM1 (0.45) | GLSSLC6A9KCNH2CARM1PRMT6 | |
| SCHEMBL3774870 | 0.83 | DRD4 (0.39) | GLSSLC6A9KCNH2MAPK1FLT1 | |
| SCHEMBL15967271 | 0.83 | GLS (0.44) | GLSFLT1KDRROCK2ROCK1 | |
| SCHEMBL5517997 | 0.82 | CARM1 (0.46) | GLSSLC6A9KCNH2CARM1PRMT6 | |
| SCHEMBL5511375 | 0.82 | GLS (0.44) | GLSSLC6A9KCNH2CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |