Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.77 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.46 |
| ▸ | HTR3B | O95264 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29585607 | 0.88 | — | — | |
| SCHEMBL5311 | 0.88 | — | — | |
| Bromide SCHEMBL31513705 | 0.86 | PNMT (0.95) | PNMTLOXL2MAOBTAAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL6928973 | 0.86 | PNMT (0.95) | PNMTLOXL2MAOBTAAR1CYP3A4 | |
| Iodide SCHEMBL31185484 | 0.86 | PNMT (0.95) | PNMTLOXL2MAOBTAAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL31185435 | 0.86 | PNMT (0.95) | PNMTLOXL2MAOBTAAR1CYP3A4 | |
| Iodide SCHEMBL28652766 | 0.86 | PNMT (0.95) | PNMTLOXL2MAOBTAAR1CYP3A4 | |
| SCHEMBL6287589 | 0.82 | CYP3A4 (0.57) | PNMTMAOBTAAR1CYP3A4GRIN2B | |
| SCHEMBL8352758 | 0.81 | LOXL2 (0.76) | PNMTLOXL2MAOBTAAR1 | |
| Benzylamine SCHEMBL19210834 | 0.79 | LOXL2 (0.80) | LOXL2MAOBTAAR1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | claimed |