Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.36 |
| ▸ | GSK3A | P49840 | 5/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | STK3 | Q13188 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31419193 | 0.82 | NPC1 (0.41) | AHRPDK2PDE3BPDE3AGSK3B | |
| SCHEMBL29550002 | 0.72 | AHR (0.48) | AHRPDK2PDE3BPDE3AGSK3B | |
| SCHEMBL5503921 | 0.72 | AHR (0.35) | AHRPDK2PDE3BPDE3ACMA1 | |
| SCHEMBL659375 | 0.72 | AHR (0.48) | AHRPDK2PDE3BPDE3AGSK3B | |
| SCHEMBL4156128 | 0.68 | — | — | |
| SCHEMBL6078864 | 0.68 | MAOA (0.41) | PDE3BPDE3AGSK3BGSK3AALDH1A1 | |
| SCHEMBL5259954 | 0.68 | MAOA (0.41) | PDE3BPDE3AGSK3BGSK3AALDH1A1 | |
| SCHEMBL16652264 | 0.68 | MMP12 (0.40) | GSK3BGSK3ACDK5PLK4AURKA | |
| SCHEMBL5501537 | 0.68 | AURKA (0.41) | AHRPDK2PDE3BPDE3AGSK3B | |
| SCHEMBL658555 | 0.67 | AHR (0.46) | AHRPDK2PDE3BPDE3ACMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005470-B1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| US-6294532-B1 | TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. | ZENECA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |
| EP-1005470-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010349-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |