Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.33 |
| ▸ | ATP4B | P51164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | SLC8A1 | P32418 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508128 | 1.00 | RAB9A (0.35) | RAB9AATP4AATP4BHSD11B1RIPK1 | |
| SCHEMBL4964984 | 0.90 | RAB9A (0.39) | RAB9ARIPK1SLC8A1 | |
| SCHEMBL4666535 | 0.90 | RAB9A (0.39) | RAB9ARIPK1SLC8A1 | |
| SCHEMBL5506546 | 0.89 | ATP4A (0.35) | RAB9AATP4AATP4BHSD11B1 | |
| SCHEMBL4664623 | 0.88 | RAB9A (0.39) | RAB9ARIPK1SLC8A1 | |
| SCHEMBL5507104 | 0.86 | ATP4A (0.33) | RAB9AATP4AATP4B | |
| SCHEMBL5511902 | 0.86 | ATP4A (0.33) | RAB9AATP4AATP4B | |
| SCHEMBL4664869 | 0.86 | MEN1 (0.39) | RAB9ARIPK1SLC8A1 | |
| SCHEMBL5511615 | 0.86 | ATP4A (0.33) | RAB9AATP4AATP4B | |
| SCHEMBL6019450 | 0.85 | DHODH (0.36) | RAB9AATP4AATP4BHSD11B1SLC8A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863820-A1 | THIOAMIDE-SUBSTITUTED TRICYCLIC BENZIMIDAZOLES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISEASES | Nycomed GmbH (DE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006100255-A1 | THIOAMIDE-SUBSTITUTED TRICYCLIC BENZIMIDAZOLES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISEASES | NYCOMED GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |