Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218537 | 0.84 | ALDH1A1 (0.43) | GAANPC1RAB9AHCRTR1HCRTR2 | |
| SCHEMBL1685064 | 0.83 | PIK3CD (0.46) | ALOX5APFEN1HCRTR1HCRTR2PIK3CD | |
| SCHEMBL5509069 | 0.81 | TYK2 (0.39) | PLK1ALOX5APFEN1GAAABL1 | |
| Hydrochloric Acid SCHEMBL6218930 | 0.80 | MEN1 (0.41) | ALOX5APABL1JAK3TP53HCRTR1 | |
| SCHEMBL21384934 | 0.78 | KDM4E (0.49) | PLK1FEN1GAATP53NPC1 | |
| SCHEMBL27894364 | 0.74 | MKNK1 (0.56) | TP53MKNK1MKNK2KDM4EKMT2A | |
| SCHEMBL26530879 | 0.74 | KDM4E (0.40) | ABL1HCRTR1HCRTR2IMPDH2CD38 | |
| SCHEMBL19302794 | 0.73 | MKNK1 (0.54) | PLK1NPC1RAB9AMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL5508208 | 0.72 | JAK2 (0.34) | ABL1JAK2JAK1TYK2JAK3 | |
| SCHEMBL19894025 | 0.71 | RAB9A (0.45) | GAANPC1RAB9APIK3CDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786792-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY | Astellas Pharma Inc. (JP) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006011631-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY | ASTELLAS PHARMA INC. (JP) | 2006-02-02 | — | — | WO | disclosed |