Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | LCAT | P04180 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.38 |
| ▸ | DLK1 | P80370 | 1/20 | 0.38 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.37 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699428 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL2699962 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL2699432 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL550934 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL548640 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL549724 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL551416 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL548641 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL4790365 | 0.91 | HSD11B1 (0.47) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL4723036 | 0.91 | HSD11B1 (0.47) | HSD11B1HTR7LCATHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |