Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | LCAT | P04180 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.38 |
| ▸ | DLK1 | P80370 | 1/20 | 0.38 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.37 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699428 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL2699962 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL550933 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL550934 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL548640 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL549724 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL551416 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL548641 | 1.00 | HSD11B1 (0.46) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL4790365 | 0.91 | HSD11B1 (0.47) | HSD11B1HTR7LCATHCRTR1HCRTR2 | |
| SCHEMBL4723036 | 0.91 | HSD11B1 (0.47) | HSD11B1HTR7LCATHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2450351-A1 | Lactam compounds and their use as pharmaceuticals | Incyte Corporation (US) | 2012-05-09 | — | — | EP | claimed |
| US-20060116382-A1 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-01 | — | — | US | claimed |
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |
| EP-2450351-A1 | Lactam compounds and their use as pharmaceuticals | Incyte Corporation (US) | 2012-05-09 | — | — | EP | disclosed |
| US-20060116382-A1 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116382-A1 | Lactam compounds and their use as pharmaceuticals | HSD11B1, HSD11B2, HSD17B1 | HSD11B1 1/4885HTR7 3714/4885LCAT 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.