Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2923825 | 1.00 | REN (0.42) | RENMAPTCYP3A4SMPD1PIK3CG | |
| SCHEMBL2914734 | 0.86 | TSHR (0.40) | RENMAPTCYP3A4SMPD1PIK3CG | |
| SCHEMBL2924802 | 0.86 | TSHR (0.40) | RENMAPTCYP3A4SMPD1PIK3CG | |
| SCHEMBL3464412 | 0.86 | REN (0.37) | RENMAPTCYP3A4THRBCYP2D6 | |
| SCHEMBL2923764 | 0.86 | REN (0.37) | RENMAPTCYP3A4THRBCYP2D6 | |
| SCHEMBL8466898 | 0.85 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL3557454 | 0.84 | REN (0.34) | RENMAPTCYP3A4POLBCYP2C19 | |
| SCHEMBL3553031 | 0.83 | REN (0.41) | RENMAPTCYP3A4SMPD1PIK3CG | |
| SCHEMBL2921036 | 0.82 | REN (0.42) | RENMAPTCYP3A4SMPD1PIK3CG | |
| SCHEMBL4647385 | 0.81 | MAPT (0.41) | RENMAPTCYP3A4SMPD1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863803-A2 | SUBSTITUTED PIPERIDINES | Speedel Experimenta AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103277-A2 | 2 , 4 , 5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |