Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 9/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115848 | 0.88 | CYP11B2 (0.40) | CYP11B2CYP11B1MKNK1MKNK2CYP1A2 | |
| SCHEMBL5503892 | 0.88 | QDPR (0.36) | MKNK1MKNK2ERN1PIM1 | |
| SCHEMBL5119729 | 0.81 | CYP11B2 (0.45) | CYP11B2CYP11B1MKNK1MKNK2CYP1A2 | |
| SCHEMBL5507937 | 0.79 | PIM1 (0.37) | CYP11B2CYP11B1MKNK1MKNK2CYP1A2 | |
| SCHEMBL5511585 | 0.78 | HTR2C (0.39) | CYP1A2CYP3A4KDM4EPIM1USP2 | |
| SCHEMBL13395064 | 0.75 | CYP11B2 (0.39) | CYP11B2CYP11B1CYP1A2ERN1 | |
| SCHEMBL3188918 | 0.75 | CYP11B2 (0.39) | CYP11B2CYP11B1CYP1A2ERN1 | |
| SCHEMBL5094733 | 0.72 | MKNK1 (0.41) | CYP11B2CYP11B1MKNK1MKNK2CYP1A2 | |
| SCHEMBL5507974 | 0.69 | MKNK1 (0.36) | CYP11B2CYP11B1MKNK1MKNK2CYP1A2 | |
| SCHEMBL5119736 | 0.69 | PIM1 (0.40) | MKNK1MKNK2PIM1ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |