Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499959 | 0.89 | CYP11B1 (0.38) | CYP11B2CYP11B1CYP1A2NPY5RCNR1 | |
| SCHEMBL5501184 | 0.89 | NPY5R (0.35) | NPY5RGRM2 | |
| SCHEMBL5502995 | 0.87 | NPY5R (0.38) | CYP11B2CYP11B1CYP1A2NPY5RCNR1 | |
| SCHEMBL5502793 | 0.85 | GRM2 (0.39) | CNR1GRM2 | |
| SCHEMBL5504107 | 0.84 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP1A2KDM4ECNR1 | |
| Hydrochloric Acid SCHEMBL5504176 | 0.83 | CYP11B2 (0.40) | CYP11B2CYP11B1CYP1A2KDM4ECNR1 | |
| SCHEMBL5504560 | 0.82 | BTK (0.38) | — | |
| SCHEMBL3945085 | 0.80 | CYP11B2 (0.38) | CYP11B2CYP11B1CYP1A2NPY5RKDM4E | |
| SCHEMBL5504727 | 0.80 | NPY5R (0.37) | CYP11B2CYP11B1CYP1A2NPY5RKDM4E | |
| SCHEMBL5503441 | 0.78 | TACR1 (0.36) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |