Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946945 | 0.84 | NPY5R (0.40) | NPY5RDPP4DPP8DPP9CNR1 | |
| SCHEMBL5504107 | 0.83 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP1A2PDE5APDE1A | |
| Hydrochloric Acid SCHEMBL5504176 | 0.82 | CYP11B2 (0.40) | CYP11B2CYP11B1CYP1A2PDE5APDE1A | |
| SCHEMBL3941646 | 0.81 | DPP4 (0.37) | NPY5RDPP4DPP8DPP9OPRL1 | |
| SCHEMBL5509855 | 0.80 | CYP11B2 (0.39) | CYP11B2CYP11B1CYP1A2NPY5RPDE5A | |
| SCHEMBL4206238 | 0.76 | VNN1 (0.36) | NPY5RPDE5APDE1APDE1BPDE4D | |
| SCHEMBL4198712 | 0.76 | PDE7B (0.36) | NPY5RPDE5APDE1APDE1BPDE4D | |
| SCHEMBL5499996 | 0.74 | CNR1 (0.38) | CYP11B2CYP11B1CYP1A2HCRTR1HCRTR2 | |
| SCHEMBL474681 | 0.73 | CYP11B2 (0.39) | CYP11B2CYP11B1CYP1A2PDE5APDE1A | |
| Hydrochloric Acid SCHEMBL5504549 | 0.73 | CNR1 (0.38) | CYP11B2CYP11B1CYP1A2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Eli Lilly & Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007127704-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |