SCHEMBL5509902

SCHEMBL5509902

COc1cc(OC)c(C=CC(N)=O)c(OC)c1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 6/20 0.66
MAOA P21397 2/20 0.57
AURKA O14965 1/20 0.55
ALDH1A1 P00352 2/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CYP1A1 P04798 2/20 0.51
CYP1B1 Q16678 2/20 0.51
PTGS2 P35354 2/20 0.50
CHRNA7 P36544 1/20 0.50
ERN1 O75460 1/20 0.50
CYP1A2 P05177 1/20 0.49
MEN1 O00255 1/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.46
PDE4A P27815 1/20 0.44
PDE4B Q07343 1/20 0.44
PDE4C Q08493 1/20 0.44
PDE4D Q08499 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5554168 0.86 ALDH1A1 (0.53) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL5554175 0.86 ALDH1A1 (0.53) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL715946 0.84 ALDH1A1 (0.74) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL1877387 0.84 ABCG2 (0.68) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL1877390 0.84 ABCG2 (0.68) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL290189 0.84 ALDH1A1 (0.74) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL1881669 0.82 ABCG2 (0.66) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL1881666 0.82 ABCG2 (0.66) ABCG2MAOAAURKAALDH1A1SMN1; SMN2
SCHEMBL4446391 0.81 ABCG2 (0.73) ABCG2MAOAAURKAALDH1A1CHRNA7
SCHEMBL26445244 0.81 ABCG2 (0.64) ABCG2MAOAAURKAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017023912-A1 2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2017-02-09 WO disclosed
EP-1539675-A4 ARYL AND HETEROARYL PROPENE AMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF UNIV TEMPLE (US) 2007-07-11 EP disclosed
EP-1539675-A2 ARYL AND HETEROARYL PROPENE AMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF Temple University of the Commonwealth System of Higher Education (US) 2005-06-15 EP disclosed
WO-2004037751-A2 ARYL AND HETEROARYL PROPENE AMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2004-05-06 WO disclosed