Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5510251 | 0.80 | TOP2A (0.48) | MEN1PKMKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5503230 | 0.78 | HPGDS (0.41) | MEN1PKMKMT2A | |
| SCHEMBL5506586 | 0.77 | KMT2A (0.76) | MEN1PKMKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5505918 | 0.74 | KMT2A (0.77) | MEN1PKMKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5505490 | 0.73 | KMT2A (0.65) | MEN1PKMKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9011271 | 0.70 | CCKBR (0.49) | — | |
| SCHEMBL5501700 | 0.70 | TOP2A (0.46) | MEN1PKMKMT2AMAPTTOP2A | |
| SCHEMBL2052464 | 0.70 | MEN1 (0.57) | MEN1PKMKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5501450 | 0.69 | KMT2A (0.76) | MEN1PKMKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2045638 | 0.69 | KMT2A (0.79) | MEN1PKMKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753724-A1 | HETEROCYCLIC DERIVATIVES FOR TREATMENT OF HYPERLIPIDEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123686-A1 | HETEROCYCLIC DERIVATIVES FOR TREATMENT OF HYPERLIPIDEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |