Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.61 |
| ▸ | CACNA1I | Q9P0X4 | 13/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967359 | 0.85 | OPRM1 (0.54) | CACNA1HCACNA1IKCNH2P2RX7RAB9A | |
| Hydrochloric Acid SCHEMBL708457 | 0.84 | OPRM1 (0.53) | CACNA1HCACNA1IKCNH2P2RX7RAB9A | |
| SCHEMBL5506769 | 0.81 | HPGD (0.54) | CACNA1IKCNH2RAB9A | |
| SCHEMBL15967240 | 0.80 | KCNH2 (0.47) | CACNA1HCACNA1IKCNH2 | |
| Hydrochloric Acid SCHEMBL709864 | 0.79 | KCNH2 (0.46) | CACNA1HCACNA1IKCNH2 | |
| SCHEMBL5509006 | 0.77 | POLB (0.54) | P2RX7RAB9A | |
| SCHEMBL29364186 | 0.76 | CACNA1H (1.00) | CACNA1HCACNA1IKCNH2CACNA1GCHRM2 | |
| SCHEMBL20328320 | 0.76 | CACNA1H (1.00) | CACNA1HCACNA1IKCNH2CACNA1GCHRM2 | |
| SCHEMBL710113 | 0.74 | KCNH2 (0.46) | CACNA1HCACNA1IKCNH2 | |
| SCHEMBL3776499 | 0.73 | CACNA1H (0.49) | CACNA1HCACNA1IKCNH2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | Pfizer Products Incorporated (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006106425-A1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |