SCHEMBL551114

SCHEMBL551114

Cc1cc(Cc2cc(C(F)(F)C(F)(F)F)cc(C(F)(F)C(F)(F)F)c2)ccc1N1C(=O)c2cccc(Cl)c2C1=O

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 13/20 0.44
GRM4 Q14833 13/20 0.44
LMNA P02545 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
GRM7 Q14831 1/20 0.39
CHRM5 P08912 1/20 0.38
CHRM3 P20309 1/20 0.38
BRD1 O95696 1/20 0.35
TAF1 P21675 1/20 0.35
BRPF1 P55201 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL551232 0.92 GRM1 (0.46) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL2889309 0.82 GRM1 (0.41) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL2887938 0.81 GRM1 (0.40) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL5429466 0.80 GRM1 (0.51) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL2889428 0.78 GRM1 (0.41) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL2891957 0.78 GRM1 (0.41) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL2892277 0.77 GRM1 (0.44) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL3327139 0.76 GRM1 (0.40) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL2889604 0.76 GRM1 (0.44) GRM1GRM4LMNASMN1; SMN2GRM7
SCHEMBL2884250 0.75 GRM4 (0.41) GRM1GRM4LMNASMN1; SMN2GRM7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8110689-B2 Benzanilides with insecticidal activity BAYER CROPSCIENE AG (DE) 2012-02-07 US disclosed
US-20100062937-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY BAYER CROPSCIENCE AG (DE) 2010-03-11 US disclosed
EP-1893567-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY Bayer CropScience AG (DE) 2008-03-05 EP disclosed
WO-2006133823-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY BAYER CROPSCIENCE AG (DE) 2006-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100062937-A1 BENZANILIDES WITH INSECTICIDAL ACTIVITY CBR3, HCN3, HAX1 GRM1 4419/4885GRM4 4646/4885LMNA 823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.