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HCN3

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 · Q9P1Z3 · HCN3 on Sugi Atlas →

78 patent compounds predicted against HCN3, 38 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL16511268 SCHEMBL16511268 0.60 1/20
SCHEMBL16511270 SCHEMBL16511270 0.58 1/20
SCHEMBL16510722 SCHEMBL16510722 0.57 1/20
SCHEMBL6633255 SCHEMBL6633255 0.56 1/20
SCHEMBL16510726 SCHEMBL16510726 0.56 1/20
SCHEMBL4354591 SCHEMBL4354591 0.51 1/20
SCHEMBL4358768 SCHEMBL4358768 0.51 1/20
SCHEMBL13706906 SCHEMBL13706906 0.51 1/20
SCHEMBL13706946 SCHEMBL13706946 0.50 1/20
SCHEMBL2469491 SCHEMBL2469491 0.48 1/20
SCHEMBL4374590 SCHEMBL4374590 0.48 1/20
SCHEMBL7398258 SCHEMBL7398258 0.48 1/20
SCHEMBL4374231 SCHEMBL4374231 0.47 1/20
SCHEMBL7362659 SCHEMBL7362659 0.46 1/20
SCHEMBL13570452 SCHEMBL13570452 0.45 1/20
SCHEMBL29003856 SCHEMBL29003856 0.45 1/20
SCHEMBL5666316 SCHEMBL5666316 0.44 1/20
SCHEMBL16511279 SCHEMBL16511279 0.44 1/20
SCHEMBL7397897 SCHEMBL7397897 0.44 1/20
SCHEMBL9283305 SCHEMBL9283305 0.43 1/20

Clinical trials — most relevant to HCN3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Personalized Real-Time DBS and PD Mechanisms PHASE4RECRUITING
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK) PHASE2/PHASE3RECRUITING
Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy PHASE3COMPLETED
Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial PHASE2WITHDRAWN
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN) PHASE1/PHASE2RECRUITING
Ultra-Early Gamma Knife Stereotactic Radiosurgery for TN PHASE2RECRUITING
HNC: Human Neural Circuits Electrophysiology During Cognition PHASE1RECRUITING
High Definition Cathodal Transcranial Direct Current Stimulation for Treatment of Refractory Partial Onset Epilepsy PHASE1COMPLETED
Peripheral KV7 Activation for Pain Relief EARLY_PHASE1COMPLETED
Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM) nanCOMPLETED
The Use of Antiarrhythmic Drugs in Pediatrics nanUNKNOWN
Measuring Single Neuron Activity in the Brain nanNOT_YET_RECRUITING
Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome nanCOMPLETED
Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings nanCOMPLETED
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
MS Fatigue and tDCS on Fatigue in Multiple Sclerosis nanCOMPLETED
Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia nanCOMPLETED
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
Safety of Oral Resin for Treatment of Hyperkalemia in Chinese Patients With Renal Insufficiency nanCOMPLETED
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development nanRECRUITING
A Multicenter, Prospective, Non-interventional Cohort Study to Evaluate the Safety and Treatment Pattern of Sodium Zirconium Cyclosilicate for Hyperkalaemia Management in Real World Practice in China nanCOMPLETED
The Energetic Origin of Neurodegeneration in MS nanCOMPLETED
Na+ Channel mRNA Regulation in Heart Failure nanCOMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Mechanism and Dosimetry Exploration in TES Magnetic Resonance Current Mapping Methods nanCOMPLETED
Role of KATP Channel Loss in Type 2 Diabetes nanRECRUITING
Dexmedetomidine Combined With Bupivacaine in Ultrasound-guided Pecto-Intercostal Fascial Block in Cardiac Surgery nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a HCN3 binder may also engage these)

ProteinNameSimilarity
O88705 — 1.000 O88705 →
Q9JKA8 — 1.000 Q9JKA8 →
Q9JKA9 — 0.990 Q9JKA9 →
Q9TV66 — 0.987 Q9TV66 →
O88703 — 0.987 O88703 →
HCN2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 0.986 landscape →
Q9JKA7 — 0.984 Q9JKA7 →
HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 0.984 landscape →
Q9MZS1 — 0.981 Q9MZS1 →
HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 0.980 landscape →
O54853 — 0.980 O54853 →
O70507 — 0.980 O70507 →
Q9JKB0 — 0.979 Q9JKB0 →
Q9R1T9 — 0.979 Q9R1T9 →
Q9TUI4 — 0.978 Q9TUI4 →
Q60603 — 0.977 Q60603 →
KCNH3 Voltage-gated inwardly rectifying potassium channel KCNH3 0.976 landscape →
O88704 — 0.976 O88704 →
O89047 — 0.976 O89047 →
Q9WVJ0 — 0.974 Q9WVJ0 →
Q8WNY2 — 0.974 Q8WNY2 →
O35219 — 0.974 O35219 →
O08962 — 0.973 O08962 →
P55934 — 0.973 P55934 →
Q9H252 — 0.973 Q9H252 →
KCNH2 Voltage-gated inwardly rectifying potassium channel KCNH2 0.972 landscape →
Q63472 — 0.972 Q63472 →
Q29441 — 0.972 Q29441 →
O18965 — 0.972 O18965 →
Q9TSZ3 — 0.972 Q9TSZ3 →