Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.56 |
| ▸ | THRA | P10827 | 6/20 | 0.43 |
| ▸ | THRB | P10828 | 6/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 6/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12740609 | 0.77 | HCAR2 (0.48) | HCAR2HCAR3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL877436 | 0.76 | HCAR2 (0.52) | HCAR2THRATHRBCCNA2CDK2 | |
| SCHEMBL1204783 | 0.75 | HCAR2 (0.46) | HCAR2HCAR3PRKAB2PRKAG1PRKAA2 | |
| Hydrochloric Acid SCHEMBL1371875 | 0.74 | HCAR2 (0.50) | HCAR2THRATHRBCCNA2CDK2 | |
| SCHEMBL5989046 | 0.73 | HCAR2 (0.37) | HCAR2THRATHRB | |
| SCHEMBL1206441 | 0.73 | HCAR2 (0.44) | HCAR2HCAR3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL28845246 | 0.73 | HCAR2 (0.44) | HCAR2HCAR3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1592992 | 0.72 | GABRA5 (0.43) | HCAR2THRATHRB | |
| SCHEMBL16619358 | 0.72 | HCAR2 (0.43) | HCAR2HCAR3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1739326 | 0.72 | HCAR2 (1.00) | HCAR2HCAR3KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367666-B2 | 3-carbamoyl-2-pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8367666-B2 | 3-carbamoyl-2-pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8178681-B2 | methyl 3-methyl-2-{[2-oxo-1-(2-oxo-ethyl)-1,2,5,6,7,8,9,10-octahydro-cycloocta[b]pyridine-3-carbonyl]-amino}-butyrate; cannabinoid receptor agonist; antiinflammatory agent, immunostimulant, analgesic; atopic dermatitis; excellent in photostability, and have excellent transdermal and oral absorbency | SHIONOGI & CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |