Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | IDH2 | P48735 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495504 | 0.75 | CNR1 (0.47) | CNR1IDH2SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5523916 | 0.75 | KCNK3 (0.52) | HPGDNPC1RAB9AIKBKETBK1 | |
| SCHEMBL5495932 | 0.72 | RAB9A (0.54) | GAASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL5501205 | 0.71 | CTSC (0.62) | SMN1; SMN2MAPTNPC1RAB9AIKBKE | |
| SCHEMBL5495448 | 0.71 | RHOA (0.53) | ALDH1A1GAANPC1RAB9AAURKA | |
| SCHEMBL5494755 | 0.70 | CTSC (0.64) | CNR1ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5513122 | 0.70 | CTSC (0.52) | EGFRCNR1IKBKETBK1CTSC | |
| SCHEMBL5496471 | 0.69 | CTSC (0.49) | CNR1ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5534432 | 0.68 | CTSC (0.52) | EGFRCNR1ALDH1A1MAPTRAB9A | |
| SCHEMBL13648229 | 0.68 | SMN1; SMN2 (0.70) | ALDH1A1GAAHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | disclosed |