Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621435 | 0.87 | TDP1 (0.41) | TDP1MAPTLMNATP53KMT2A | |
| SCHEMBL5510395 | 0.86 | MEN1 (0.46) | TDP1LMNAKMT2AALDH1A1GAA | |
| SCHEMBL5509703 | 0.83 | GLA (0.43) | TDP1MAPTLMNATP53STS | |
| SCHEMBL5509086 | 0.81 | BRD4 (0.48) | NR1H2TDP1MAPTLMNATP53 | |
| SCHEMBL5514925 | 0.81 | MAPT (0.41) | TDP1MAPTLMNATP53ALDH1A1 | |
| SCHEMBL27720095 | 0.81 | MAPT (0.40) | TDP1MAPTLMNATP53KMT2A | |
| SCHEMBL5516306 | 0.81 | ALDH1A1 (0.44) | NR1H2TDP1LMNATP53KMT2A | |
| SCHEMBL3996870 | 0.81 | BRD4 (0.47) | NR1H2TDP1LMNATP53KMT2A | |
| SCHEMBL5507312 | 0.80 | BRD4 (0.51) | TP53GAAHTTBRD4 | |
| Tert-Butyl Formate SCHEMBL27720068 | 0.75 | BRD4 (0.38) | NR1H2TDP1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |