Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5513644 | 1.00 | KDM4E (0.36) | KDM4EKCNH2CYP8B1MAP4K4PIK3CD | |
| SCHEMBL15169318 | 0.79 | NR1H2 (0.34) | KDM4EHCRTR1HCRTR2GPR119 | |
| SCHEMBL1148019 | 0.79 | KCNH2 (0.39) | KCNH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1148017 | 0.79 | KCNH2 (0.39) | KCNH2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15169748 | 0.75 | GPR119 (0.37) | KDM4EGPR119 | |
| SCHEMBL15179608 | 0.73 | STS (0.42) | KDM4EGPR119 | |
| SCHEMBL15169774 | 0.71 | NR1H2 (0.38) | KDM4EHCRTR1HCRTR2GPR119 | |
| SCHEMBL4550833 | 0.71 | STS (0.38) | KDM4E | |
| SCHEMBL4550488 | 0.71 | UCHL1 (0.35) | — | |
| SCHEMBL3956506 | 0.70 | MAP4K4 (0.39) | CYP8B1MAP4K4PIK3CDPOLBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |