Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.75 |
| ▸ | MMP2 | P08253 | 2/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.75 |
| ▸ | COMT | P21964 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | METAP2 | P50579 | 1/20 | 0.75 |
| ▸ | METAP1 | P53582 | 1/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276385 | 0.89 | METAP2 (0.54) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL29577533 | 0.89 | METAP2 (0.54) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL5824010 | 0.87 | TSHR (0.78) | TSHRMMP2CHRM1COMTADRA1A | |
| Oxyquinoline SCHEMBL22115717 | 0.87 | TSHR (0.66) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL28351928 | 0.87 | METAP2 (0.52) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL30203848 | 0.87 | METAP2 (0.52) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL28745782 | 0.87 | METAP2 (0.52) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL28613178 | 0.87 | METAP2 (0.52) | TSHRMMP2CHRM1COMTADRA1A | |
| SCHEMBL29683153 | 0.87 | METAP2 (0.52) | TSHRMMP2CHRM1COMTADRA1A | |
| Hydrochloric Acid SCHEMBL28047423 | 0.87 | METAP2 (0.52) | TSHRMMP2CHRM1COMTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |