Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5512095 | 0.81 | KDM4E (0.35) | KDM4EALDH1A1ATMSLC6A4 | |
| Hydrochloric Acid SCHEMBL5518571 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL7196605 | 0.77 | KDM4E (0.41) | KDM4EALDH1A1HTR1AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL3918950 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1ATMHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL5515714 | 0.73 | CYP11B1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL6890919 | 0.72 | KDM4E (0.41) | KDM4EALDH1A1HTR1AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL6886360 | 0.72 | KDM4E (0.41) | KDM4EALDH1A1HTR1AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL6889779 | 0.72 | KDM4E (0.41) | KDM4EALDH1A1HTR1AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL7935816 | 0.71 | KDM4E (0.40) | KDM4EALDH1A1SLC6A4 | |
| Hydrochloric Acid SCHEMBL5613031 | 0.71 | KDM4E (0.40) | KDM4EALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7208559-B2 | Ethylened polymer and molded object obtained therefrom | MITSUI CHEMICALS, INC. (JP) | 2007-04-24 | — | — | US | disclosed |
| US-20060135712-A1 | Ethylened polymer and molded object obtained therefrom | MITSUI CHEMICALS, INC. (JP) | 2006-06-22 | — | — | US | disclosed |