SCHEMBL5515014

SCHEMBL5515014

O=C1C2C3C=CC(C3)C2C(=O)N1c1ccccc1Cl

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
SMN1; SMN2 Q16637 3/20 0.56
TSHR P16473 2/20 0.54
ESR2 Q92731 1/20 0.54
ALDH1A1 P00352 2/20 0.53
GRM4 Q14833 1/20 0.53
GRM1 Q13255 1/20 0.53
MAPT P10636 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14494293 0.86 MEN1 (0.48) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL3200834 0.81 MEN1 (0.52) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL4592017 0.81 MEN1 (0.52) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL3200843 0.81 MEN1 (0.52) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL5511070 0.81 KDM4E (0.52) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL3196336 0.81 MEN1 (0.63) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL29625376 0.81 MEN1 (0.63) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL5511033 0.81 GRM4 (0.54) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL5515973 0.81 GAA (0.48) MEN1KMT2ASMN1; SMN2TSHRESR2
SCHEMBL31525082 0.80 MEN1 (0.66) MEN1KMT2ASMN1; SMN2TSHRESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7230058-B2 Ring-opened polynorbornenes JSR CORPORATION (JP) 2007-06-12 US disclosed
US-7230058-B2 Ring-opened polynorbornenes JSR CORPORATION (JP) 2007-06-12 US disclosed
US-7230058-B2 Ring-opened polynorbornenes JSR CORPORATION (JP) 2007-06-12 US disclosed
US-7157523-B2 Ring-opened polynorbornenes JSR CORPORATION (JP) 2007-01-02 US disclosed
US-7157523-B2 Ring-opened polynorbornenes JSR CORPORATION (JP) 2007-01-02 US disclosed
US-7157523-B2 Ring-opened polynorbornenes JSR CORPORATION (JP) 2007-01-02 US disclosed
US-20060189771-A1 Ring-opened polynorbornenes JSR CORPORATION (JP) 2006-08-24 US disclosed
US-20060041092-A1 Ring-opened polynorbornenes JSR CORPORATION (JP) 2006-02-23 US disclosed
EP-1561766-A1 RING-OPENED POLYNORBORNENES JSR Corporation (JP) 2005-08-10 EP disclosed