Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | ITGAV | P06756 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749757 | 0.97 | ITGB3 (0.56) | ITGB3ITGA2BHDAC8ITGAVCTSS | |
| SCHEMBL3735130 | 0.94 | ITGB3 (0.49) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3743063 | 0.93 | ITGB3 (0.53) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3730050 | 0.93 | ITGB3 (0.55) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3742534 | 0.93 | HDAC8 (0.55) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3730018 | 0.91 | SRC (0.55) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3736640 | 0.90 | SRC (0.58) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3742962 | 0.90 | CTSS (0.52) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3737601 | 0.89 | ITGB3 (0.49) | ITGB3ITGA2BHDAC8CTSSCTSK | |
| SCHEMBL3798555 | 0.88 | PTPN1 (0.47) | ITGB3ITGA2BHDAC8CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812012-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | Ceptyr, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006055525-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | CEPTYR, INC. (US) | 2006-05-26 | — | — | WO | disclosed |