SCHEMBL5516539

SCHEMBL5516539

O=C(O)CN/C=C1/N=C(c2ccccc2)OC1=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.51
CSNK2A2 P19784 3/20 0.50
CSNK2B P67870 3/20 0.50
CSNK2A1 P68400 3/20 0.50
NPC1 O15118 4/20 0.49
RAB9A P51151 4/20 0.49
F2 P00734 1/20 0.46
F10 P00742 1/20 0.46
PLG P00747 1/20 0.46
PLAU P00749 1/20 0.46
PLAT P00750 1/20 0.46
KLKB1 P03952 1/20 0.46
DAPK3 O43293 1/20 0.46
PLCG2 P16885 1/20 0.45
KEAP1 Q14145 1/20 0.44
NFE2L2 Q16236 1/20 0.44
MAPT P10636 3/20 0.44
ALDH1A1 P00352 3/20 0.44
LMNA P02545 1/20 0.44
RECQL P46063 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5516544 1.00 SMN1; SMN2 (0.51) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1
SCHEMBL2313102 0.84 CSNK2A2 (0.49) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1
SCHEMBL2313095 0.84 CSNK2A2 (0.49) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1
SCHEMBL4804018 0.75 SMN1; SMN2 (0.63) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1
SCHEMBL12450700 0.75 SMN1; SMN2 (0.63) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1
SCHEMBL4804024 0.75 SMN1; SMN2 (0.63) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1
SCHEMBL10595203 0.73 MEN1 (0.51) SMN1; SMN2NPC1RAB9AF2DAPK3
SCHEMBL10595200 0.73 MEN1 (0.51) SMN1; SMN2NPC1RAB9AF2DAPK3
SCHEMBL24524106 0.72 SMN1; SMN2 (0.63) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1
SCHEMBL21217197 0.72 SMN1; SMN2 (0.68) SMN1; SMN2CSNK2A2CSNK2BCSNK2A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070036722-A1 Separation processes RONGVED PAL 2007-02-15 US disclosed
EP-1073716-B1 IMPROVEMENTS IN OR RELATING TO SEPARATION PROCESSES AMERSHAM HEALTH AS (NO) 2004-04-28 EP disclosed
US-20030104359-A1 Separation processes NYCOMED IMAGING AS (NO) 2003-06-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070036722-A1 Separation processes FUS, FGB, FAM83B SMN1; SMN2 1765/4885CSNK2A2 1967/4885CSNK2B 1579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.