Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.64 |
| ▸ | IGF1R | P08069 | 19/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | INSR | P06213 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135538 | 1.00 | PTK2 (0.64) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5511064 | 0.93 | IGF1R (0.69) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5136010 | 0.93 | IGF1R (0.69) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5136949 | 0.92 | PTK2 (0.76) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5135881 | 0.92 | PTK2 (0.76) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5136035 | 0.88 | IGF1R (0.73) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5136050 | 0.88 | IGF1R (0.73) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5074831 | 0.88 | IGF1R (0.73) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL6095914 | 0.88 | IGF1R (0.73) | PTK2AURKAAURKBALKIGF1R | |
| SCHEMBL5136042 | 0.88 | IGF1R (0.73) | PTK2AURKAAURKBALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081454-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2006-07-25 | — | — | US | claimed |
| US-20040044203-A1 | Novel tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-03-04 | — | — | US | claimed |
| US-7223757-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-29 | — | — | US | disclosed |
| US-7081454-B2 | Tyrosine kinase inhibitors | BRISTOL-MYERS SQUIBB CO. (US) | 2006-07-25 | — | — | US | disclosed |
| US-20060079518-A1 | Novel tyrosine kinase inhibitors | WITTMAN MARK D | 2006-04-13 | — | — | US | disclosed |
| US-20050075358-A1 | Methods for treating IGF1R-inhibitor induced hyperglycemia | BRISTOL-MYERS SQUIBB COMANY | 2005-04-07 | — | — | US | disclosed |
| US-20040209930-A1 | Synergistic methods and compositions for treating cancer | BRISTOL-MYERS SQUIBB COMPANY | 2004-10-21 | — | — | US | disclosed |
| US-20040106605-A1 | Synergistic methods and compositions for treating cancer | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-03 | — | — | US | disclosed |
| US-20040072760-A1 | Synergistic methods and compositions for treating cancer | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072760-A1 | Synergistic methods and compositions for treating cancer | IGF1R, MCL1, IGFBP2 | PTK2 164/4885AURKA 1094/4885AURKB 300/4885 |
| US-20040044203-A1 | Novel tyrosine kinase inhibitors | ABL1, YES1, FER | PTK2 54/4885AURKA 345/4885AURKB 260/4885 |
| US-20040106605-A1 | Synergistic methods and compositions for treating cancer | EGFR, IGF1R, ERBB3 | PTK2 57/4885AURKA 848/4885AURKB 357/4885 |
| US-20040209930-A1 | Synergistic methods and compositions for treating cancer | IGF1R, CHEK2, MCL1 | PTK2 51/4885AURKA 336/4885AURKB 108/4885 |
| US-20060079518-A1 | Novel tyrosine kinase inhibitors | ABL1, FER, ERBB2 | PTK2 67/4885AURKA 342/4885AURKB 266/4885 |
| US-20050075358-A1 | Methods for treating IGF1R-inhibitor induced hyperglycemia | IGF1R, IGFBP1, IRS1 | PTK2 460/4885AURKA 2296/4885AURKB 1441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.