⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4532762 | 0.82 | LMNA (0.36) | — | |
| SCHEMBL1782984 | 0.75 | GAA (0.36) | — | |
| SCHEMBL9184609 | 0.71 | — | — | |
| SCHEMBL23788874 | 0.70 | — | — | |
| SCHEMBL1783936 | 0.65 | CA1 (0.33) | — | |
| SCHEMBL1626406 | 0.65 | PGD (0.36) | — | |
| SCHEMBL25396955 | 0.65 | PGD (0.36) | — | |
| SCHEMBL2999436 | 0.65 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL27696247 | 0.64 | — | — | |
| SCHEMBL5678671 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114438004-B | Saccharopolyspora erythraea engineering strain with doubled pII gene, and construction method and application thereof | 湖南师范大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-113355339-B | Traceless fixed-point transformation method for large gene cluster and application thereof | 山东大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-114438004-A | Saccharopolyspora whiskers engineering strain with doubled pII gene and construction method and application thereof | 湖南师范大学 | 2022-05-06 | — | — | CN | disclosed |
| CN-109486848-B | Construction method and application of spinosyn-containing multi-operon artificial gene cluster plasmid | 山东大学 | 2021-10-22 | — | — | CN | disclosed |
| CN-113355339-A | Traceless fixed-point transformation method for large gene cluster and application thereof | 山东大学 | 2021-09-07 | — | — | CN | disclosed |
| CN-109486848-A | A kind of construction method containing the more operon artificial gene cluster plasmids of pleocidin and application | 山东大学 | 2019-03-19 | — | — | CN | disclosed |
| US-7285653-B1 | Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis | BAYER AKTIENGESELLSCHAFT (DE) | 2007-10-23 | — | — | US | disclosed |
| US-20060173172-A1 | Method for producing novel spinosyn derivatives | JESCHKE PETER | 2006-08-03 | — | — | US | disclosed |
| US-7034130-B2 | Method for producing novel spinosyn derivatives | BAYER CROPSCIENCE AG (DE) | 2006-04-25 | — | — | US | disclosed |
| US-20040242858-A1 | Method for producing novel spinosyn derivatives | BAYER CROPSCIENCE AG (DE) | 2004-12-02 | — | — | US | disclosed |
| US-20040147766-A1 | Intermediates for producing spinosyns | BAYER CROPSCIENCE AG (DE) | 2004-07-29 | — | — | US | disclosed |
| EP-1212412-A2 | NUCLEIC ACIDS WHICH CODE FOR THE ENZYME ACTIVITIES OF THE SPINOSYN BIOSYNTHESIS | BAYER AG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016303-A2 | NUCLEIC ACIDS WHICH CODE FOR THE ENZYME ACTIVITIES OF THE SPINOSYN BIOSYNTHESIS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-03-08 | — | — | WO | disclosed |