Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 6/20 | 0.40 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5513842 | 1.00 | TRPM5 (0.40) | TRPM5TRPM4DPP4SLC18A3SIGMAR1 | |
| SCHEMBL5513845 | 1.00 | TRPM5 (0.40) | TRPM5TRPM4DPP4SLC18A3SIGMAR1 | |
| SCHEMBL5512850 | 0.89 | TRPM5 (0.42) | TRPM5TRPM4DPP4SLC18A3SIGMAR1 | |
| SCHEMBL5512851 | 0.89 | TRPM5 (0.42) | TRPM5TRPM4DPP4SLC18A3SIGMAR1 | |
| SCHEMBL2578504 | 0.83 | TRPM5 (0.39) | TRPM5TRPM4MEN1KMT2A | |
| SCHEMBL4378522 | 0.82 | HTR2C (0.39) | — | |
| SCHEMBL14065400 | 0.80 | MEN1 (0.47) | SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL4865057 | 0.80 | MEN1 (0.47) | SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL6924404 | 0.80 | MEN1 (0.47) | SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL4373206 | 0.79 | HTR2C (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061097-A | Novel gamma secretase inhibitors | SCHERING CORP (US) | 2007-10-24 | — | — | CN | disclosed |
| US-7256186-B2 | Gamma secretase inhibitors | SCHERING CORPORATION (US) | 2007-08-14 | — | — | US | disclosed |
| US-7208602-B2 | Gamma secretase inhibitors | SCHERING CORPORATION (US) | 2007-04-24 | — | — | US | disclosed |
| EP-1663975-A1 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060100427-A1 | Novel Gamma Secretase inhibitors | SCHERING CORPORATION AND PHARMACOPEIA, INC. | 2006-05-11 | — | — | US | disclosed |
| CN-1628100-A | Gamma-secretase inhibitors | SCHERING CORP (US) | 2005-06-15 | — | — | CN | disclosed |
| US-20050085506-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION AND PHARMACOPEIA, INC. | 2005-04-21 | — | — | US | disclosed |
| WO-2005028440-A1 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
| EP-1472223-A1 | GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20040171614-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION | 2004-09-02 | — | — | US | disclosed |
| US-20040048848-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION AND PHARMACOPEIA, INC. | 2004-03-11 | — | — | US | disclosed |
| WO-2003066592-A1 | GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171614-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, APP | TRPM5 3357/4885TRPM4 4325/4885DPP4 2537/4885 |
| US-20040048848-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, PSEN1 | TRPM5 4378/4885TRPM4 4613/4885DPP4 1251/4885 |
| US-20060100427-A1 | Novel Gamma Secretase inhibitors | BACE1, BACE2, PSEN1 | TRPM5 4395/4885TRPM4 4512/4885DPP4 973/4885 |
| US-20050085506-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, APP | TRPM5 3704/4885TRPM4 4286/4885DPP4 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.