Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5342596 | 0.93 | CYP3A4 (0.55) | CYP3A4CYP2D6CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL5523656 | 0.79 | CYP2C9 (0.47) | CYP3A4CYP2C9ALDH1A1HPGDCA2 | |
| SCHEMBL10253118 | 0.78 | CYP3A4 (0.58) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD | |
| SCHEMBL21699897 | 0.78 | CYP3A4 (0.53) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD | |
| SCHEMBL19930192 | 0.77 | CYP3A4 (0.56) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD | |
| SCHEMBL30069694 | 0.77 | CYP3A4 (0.56) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD | |
| SCHEMBL30102216 | 0.77 | CYP3A4 (0.56) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD | |
| Formic Acid SCHEMBL28060935 | 0.77 | ALDH1A1 (0.61) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD | |
| SCHEMBL598023 | 0.77 | CYP3A4 (0.59) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD | |
| SCHEMBL18821767 | 0.77 | CYP3A4 (0.49) | CYP3A4CYP2D6CYP2C9ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241770-B2 | Hydronopol derivatives as agonists on human ORL1 receptors | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-07-10 | — | — | US | disclosed |
| US-20050131004-A1 | Hydronopol derivatives as agonists on human ORL1 receptors | SOLVAY PHARMACEUTICALS GMBH. | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131004-A1 | Hydronopol derivatives as agonists on human ORL1 receptors | OPRL1, ORMDL3, OGFRL1 | CYP3A4 3173/4885CYP2D6 1625/4885CYP2C9 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.