Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.45 |
| ▸ | MEN1 | O00255 | 11/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10958150 | 0.91 | MEN1 (0.46) | KMT2AMEN1MAPTNPSR1NPC1 | |
| SCHEMBL16097099 | 0.86 | KMT2A (0.60) | KMT2AMEN1MAPTNPSR1NPC1 | |
| SCHEMBL17131836 | 0.84 | MEN1 (0.58) | KMT2AMEN1MAPTNPSR1NPC1 | |
| SCHEMBL1609331 | 0.82 | LMNA (0.47) | KMT2AMEN1MAPTNPSR1NPC1 | |
| SCHEMBL1654627 | 0.79 | LMNA (0.49) | MAPTNPSR1HTTALDH1A1LMNA | |
| SCHEMBL28284559 | 0.78 | MAPT (0.45) | KMT2AMEN1MAPTNPSR1NPC1 | |
| SCHEMBL5903298 | 0.78 | MEN1 (0.45) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL29143292 | 0.77 | ALDH1A1 (0.49) | KMT2AMEN1MAPTNPSR1NPC1 | |
| SCHEMBL622372 | 0.76 | KMT2A (0.51) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL30105929 | 0.76 | KMT2A (0.51) | KMT2AMEN1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100488947-C | Serine protease inhibitors | GENENTECH INC (US) | 2009-05-20 | — | — | CN | disclosed |
| US-20070037813-A1 | Serine Protease Inhibitors | GENENTECH, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| EP-1144373-B1 | SERINE PROTEASE INHIBITORS | GENENTECH INC (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20050186198-A1 | Serine protease inhibitors | GENENTECH, INC. | 2005-08-25 | — | — | US | disclosed |
| US-6919369-B2 | Controlling blood coagulation | GENENTECH, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030212071-A1 | Serine protease inhibitors | GENENTECH, INC. | 2003-11-13 | — | — | US | disclosed |
| US-6472393-B1 | Serine protease inhibitors | GENENTECH, INC. | 2002-10-29 | — | — | US | disclosed |
| CN-1342139-A | Serine protease inhibitors | GENENTECH INC (US) | 2002-03-27 | — | — | CN | disclosed |
| EP-1144373-A3 | SERINE PROTEASE INHIBITORS | Genentech, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1144373-A2 | SERINE PROTEASE INHIBITORS | Genentech, Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000041531-A2 | SERINE PROTEASE INHIBITORS | GENENTECH, INC. (US) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212071-A1 | Serine protease inhibitors | SERPINE1, SPINT2, TFPI | KMT2A 1165/4885MEN1 995/4885MAPT 4012/4885 |
| US-20070037813-A1 | Serine Protease Inhibitors | TFPI, SPINT2, SERPINE1 | KMT2A 992/4885MEN1 1277/4885MAPT 3882/4885 |
| US-20050186198-A1 | Serine protease inhibitors | TFPI, SPINT2, SERPINE1 | KMT2A 992/4885MEN1 1277/4885MAPT 3882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.