Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | FCER2 | P06734 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781195 | 0.87 | PTPN1 (0.57) | PTPN1CTSBCTSSCTSKACE | |
| SCHEMBL31407756 | 0.87 | PTPN1 (0.57) | PTPN1CTSBCTSSCTSKACE | |
| SCHEMBL2300108 | 0.87 | PTPN1 (0.57) | PTPN1CTSBCTSSCTSKACE | |
| SCHEMBL31407747 | 0.87 | PTPN1 (0.57) | PTPN1CTSBCTSSCTSKACE | |
| SCHEMBL5524933 | 0.83 | TAS1R3 (0.42) | PTPN1TAS1R3TAS1R1FCER2 | |
| SCHEMBL2336223 | 0.83 | ACE (0.58) | CTSBCTSSCTSKACEMAPK1 | |
| SCHEMBL3882884 | 0.82 | CTSS (0.41) | CTSBCTSSCTSKTAS1R3TAS1R1 | |
| SCHEMBL2302860 | 0.80 | PTPN1 (0.58) | PTPN1ACEMAPK1ITGB3ITGA2B | |
| SCHEMBL2302074 | 0.80 | PTPN1 (0.42) | PTPN1CTSBCTSSCTSKACE | |
| SCHEMBL31407473 | 0.79 | PTPN1 (0.57) | PTPN1CTSBCTSSCTSKACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070282100-A1 | Boronic ester and acid compounds, synthesis and uses | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | US | disclosed |
| US-7119080-B2 | For use as inhibitors of proteasome; for reducing the rate of degradation of proteins in an animal | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060122390-A1 | Boronic ester and acid compounds, synthesis and uses | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | US | disclosed |
| US-6617317-B1 | Reducing the rate of degradation of proteins in an animal | MILLENNIUM PHARMACEUTICALS, INC. | 2003-09-09 | — | — | US | disclosed |
| US-6066730-A | Boronic ester and acid compounds, synthesis and uses | PROSCRIPT, INC. | 2000-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122390-A1 | Boronic ester and acid compounds, synthesis and uses | BCL6, BCAP31, CD79B | PTPN1 1875/4885CTSB 461/4885CTSS 2481/4885 |
| US-20070282100-A1 | Boronic ester and acid compounds, synthesis and uses | BCL6, BCAP31, CD79B | PTPN1 1875/4885CTSB 461/4885CTSS 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.